HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC
نویسندگان
چکیده
منابع مشابه
Protective role of HLA-DRB1*11 against juvenile idiopathic arthritis living in North Eastern Iran
Objective(s): Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases in children. The complex nature of this immune-mediated disease owes itself to several predisposing genes and environmental factors affecting its pathogenesis. Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a suscept...
متن کاملDiversity of Extended HLA-DRB1 Haplotypes in the Finnish Population
The Major Histocompatibility Complex (MHC, 6p21) codes for traditional HLA and other host response related genes. The polymorphic HLA-DRB1 gene in MHC Class II has been associated with several complex diseases. In this study we focus on MHC haplotype structures in the Finnish population. We explore the variability of extended HLA-DRB1 haplotypes in relation to the other traditional HLA genes an...
متن کاملHla and Juvenile Idiopathic Arthritis: an Overview
Juvenile Idiopathic Arthritis (JIA) is an umbrella term referring to a group of disorders characterized by chronic arthritis and is the most common chronic rheumatic illness . Although the exact etiology of JIA remains unclear, it seems to be a complex genetic trait involving the effects of multiple genes related to immunity and inflammation. This review aims to throw light on the association b...
متن کاملPADI4 and the HLA-DRB1 shared epitope in juvenile idiopathic arthritis
OBJECTIVE Both genetic and environmental factors are associated with susceptibility to juvenile idiopathic arthritis (JIA). Many studies have reported that both a 'shared epitope' (SE) encoded by several HLA-DRB1 alleles and the peptidyl arginine deiminase type 4 (PADI4) gene polymorphisms are associated with susceptibility to rheumatoid arthritis (RA). However, it is uncertain whether JIA and ...
متن کاملHLA-DRB1*11 and variants of the MHC class II locus are strong risk factors for systemic juvenile idiopathic arthritis.
Systemic juvenile idiopathic arthritis (sJIA) is an often severe, potentially life-threatening childhood inflammatory disease, the pathophysiology of which is poorly understood. To determine whether genetic variation within the MHC locus on chromosome 6 influences sJIA susceptibility, we performed an association study of 982 children with sJIA and 8,010 healthy control subjects from nine countr...
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ژورنال
عنوان ژورنال: Genes and Immunity
سال: 2004
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364129